स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
MECEE-PG – MD/MS/MDS Entrance · २,८६५ प्रश्न
२,८६५ प्रश्न उपलब्ध। मोड छान्नुहोस्:
MD/MS प्रवेश: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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Tartrate-resistant acid phosphatase (TRAP) positivity is characteristic of:
सही उत्तर: ख) Hairy cell leukaemia
Hairy cell leukaemia is a B-cell neoplasm with hair-like cytoplasmic projections, TRAP positivity and a BRAF V600E mutation. It typically presents with massive splenomegaly and a 'dry tap' on marrow aspiration.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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All-trans retinoic acid (ATRA) is a specific treatment for:
सही उत्तर: ग) Acute promyelocytic leukaemia
APL has t(15;17) producing the PML-RARA fusion protein; ATRA induces differentiation of the abnormal promyelocytes. CML is treated with tyrosine kinase inhibitors such as imatinib.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Auer rods are characteristically seen in:
सही उत्तर: ख) Acute myeloid leukaemia
Auer rods are needle-like azurophilic granule aggregates found in myeloblasts, so they indicate a myeloid lineage; they are abundant in acute promyelocytic leukaemia. They are not seen in lymphoid leukaemias.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Schiller-Duval bodies are characteristic of:
सही उत्तर: क) Yolk sac tumour
Schiller-Duval bodies are glomerulus-like structures with a central vessel, seen in yolk sac (endodermal sinus) tumour, which also secretes alpha-fetoprotein. Choriocarcinoma secretes hCG and lacks these bodies.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The tumour suppressor gene called the 'guardian of the genome' is:
सही उत्तर: ग) TP53
p53 senses DNA damage and causes G1 arrest for repair or triggers apoptosis if damage is irreparable, hence 'guardian of the genome'. It is the most commonly mutated gene in human cancers; RB is the 'governor' of the cell cycle.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The Philadelphia chromosome, characteristic of chronic myeloid leukaemia, results from:
सही उत्तर: ग) t(9;22)
The t(9;22) translocation creates the BCR-ABL fusion gene encoding a constitutively active tyrosine kinase, the target of imatinib. t(8;14) is Burkitt lymphoma and t(15;17) is acute promyelocytic leukaemia.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Vitamin C deficiency impairs wound healing mainly by defective:
सही उत्तर: ख) Hydroxylation of proline and lysine in procollagen
Ascorbic acid is a cofactor for prolyl and lysyl hydroxylases; without it, the collagen triple helix is unstable, causing scurvy. Lysyl oxidase cross-linking needs copper, not vitamin C.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Epithelioid cells seen in a granuloma are modified:
सही उत्तर: ग) Macrophages
Epithelioid cells are activated macrophages with abundant pink cytoplasm resembling epithelial cells; they may fuse to form multinucleated giant cells. Lymphocytes form a cuff around the granuloma but are not epithelioid cells.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The most common inherited cause of hypercoagulability (thrombophilia) in Caucasian populations is:
सही उत्तर: घ) Factor V Leiden mutation
Factor V Leiden (Arg506Gln) makes factor Va resistant to inactivation by activated protein C. It is far more common than deficiencies of protein C, protein S or antithrombin.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Lines of Zahn are a feature of:
सही उत्तर: घ) Thrombus formed in flowing blood (antemortem thrombus)
Lines of Zahn are alternating pale layers of platelets and fibrin and dark layers of red cells, formed in flowing blood. Their presence distinguishes an antemortem thrombus from a postmortem clot, which lacks laminations.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
यी अभ्यास प्रश्न हुन्, आधिकारिक प्रश्न होइनन्। पाठ्यक्रम, विज्ञापन र नतिजाका लागि सम्बन्धित निकायको आधिकारिक वेबसाइट हेर्नुहोस्। उत्तरमा गल्ती भेटे प्रश्नमुनिको "टिप्पणी / गल्ती रिपोर्ट" मा लेख्नुहोस्।
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