प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी – Pathology, Microbiology & Pharmacology MCQ
प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी – MD/MS प्रवेश
Pathology, Microbiology & Pharmacology · MECEE-PG – MD/MS/MDS Entrance · ४०८ प्रश्न
४०८ प्रश्न उपलब्ध। मोड छान्नुहोस्:
प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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The Philadelphia chromosome, a hallmark of Chronic Myeloid Leukemia (CML), results from which chromosomal translocation? (a) t(9;22) (b) t(8;14) (c) t(15;17) (d) t(6;11)
सही उत्तर: क) (a) t(9;22)
The Philadelphia chromosome is created by a translocation between chromosomes 9 and 22 (t(9;22)). This translocation fuses the BCR gene with the Abl tyrosine kinase gene, leading to constitutive activation of the signaling pathway that drives CML. Options b, c, and d represent other known chromosomal translocations associated with different cancers.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following medications demonstrates a pharmacokinetic profile primarily influenced by first-order elimination kinetics? a) Warfarin b) Penicillin G c) Morphine d) Diazepam
सही उत्तर: ख) b) Penicillin G
Warfarin exhibits a characteristic first-order elimination profile. This means its clearance from the body is proportional to its concentration at any given time. Options (b), (c) and (d) all demonstrate saturation kinetics.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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A patient presents with symptoms suggestive of hepatic encephalopathy. Which pharmacological intervention targeting a specific microbial pathway is MOST effective in reducing the severity of this condition? a) Administration of intravenous corticosteroids b) Oral administration of antibiotics, specifically cephalosporins c) Reduction in dietary protein intake to limit ammonia production d) Intravenous infusion of diazepam
सही उत्तर: घ) d) Intravenous infusion of diazepam
Hepatic encephalopathy is often caused by elevated levels of ammonia in the bloodstream due to bacterial metabolism of ingested protein. Reducing dietary protein directly limits the substrate for ammonia production, which reduces the neurological symptoms. Options (a), (b) and (d) are less directly related to this pathway.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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A patient is diagnosed with pneumonia caused by *Pneumocystis jirovecii*. Which of the following pathological findings would you MOST likely expect to see on a bronchoalveolar lavage sample? a) Neutrophil predominance b) Macrophages and yeast-like organisms c) Lymphocyte dominance d) Extensive alveolar hemorrhage
सही उत्तर: ख) b) Macrophages and yeast-like organisms
*Pneumocystis jirovecii* pneumonia is characterized by the presence of yeast-like organisms within the alveoli. The lavage fluid would show a significant number of these organisms alongside macrophages. Option (a) describes a neutrophilic response to bacterial infection, while options (c) and (d) are not typical findings.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following bacterial infections is MOST commonly associated with the formation of ‘golden staff’ morphology during Gram staining? a) *Escherichia coli* b) *Staphylococcus aureus* c) *Klebsiella pneumoniae* d) *Pseudomonas aeruginosa*
सही उत्तर: ख) b) *Staphylococcus aureus*
*Staphylococcus aureus* frequently produces golden staff morphology during Gram staining due to its cell wall structure. This is a key feature used in presumptive identification. Options (a), (c) and (d) do not typically produce this characteristic.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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A patient presents with symptoms consistent with disseminated intravascular coagulation (DIC). Which of the following pathological processes is MOST likely contributing to this condition? a) Chronic inflammation leading to fibrosis b) Acute endothelial activation and microthrombosis c) Lymphocytic infiltration in a solid tumor d) Granulomatous inflammation following mycobacterial infection
सही उत्तर: ख) b) Acute endothelial activation and microthrombosis
Acute endothelial activation and microthrombosis is the hallmark of DIC. This involves widespread clot formation disrupting normal blood flow and contributing to organ damage. Option (a) describes chronic fibrosis, option (c) represents neoplastic infiltration, and option (d) describes granulomatous inflammation – all of which don’t directly cause the central pathogenic mechanism of DIC.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Tetanospasmin, the bacterial toxin produced by *Clostridium tetani*, induces spastic paralysis through its action on which nerve?
सही उत्तर: ग) Motor neurons
Tetanospasmin binds to ganglionic neurons (motor neurons), disrupting inhibitory neurotransmission and causing uncontrolled muscle contractions – the hallmark of tetanus. Dopaminergic neurons are affected in Parkinson's disease, cholinergic in myasthenia gravis, and sensory neurons involved in pain perception.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Amyloidosis associated with plasma cell dyscrasias, such as multiple myeloma, is predominantly composed of which protein?
सही उत्तर: ग) Serum amyloid A (SAA)
AL amyloid is derived from the transthyretin (TTR) protein. While other immunoglobulin fragments can contribute, TTR is the primary component characteristic of AL amyloidosis. IgG and SAA are associated with different types of amyloidosis.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following best describes Virchow's triad as it relates to thrombosis?
सही उत्तर: ग) Increased vascular permeability, Inflammation, Anticoagulant activity
Virchow's triad is a foundational concept in thrombosis, stating that it results from three interconnected factors: thrombin generation (activation of the coagulation cascade), platelet aggregation, and increased vascular permeability. The other options represent alternative mechanisms or components involved in hemostasis.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following cell types is MOST directly responsible for initiating and propagating an inflammatory response characterized by neutrophil infiltration into tissues?
सही उत्तर: ख) Macrophages
Macrophages, particularly M1 macrophages, are key players in initiating and amplifying inflammation. They release cytokines like TNF-α and IL-1 which recruit neutrophils. The other options—T lymphocytes, mast cells, and eosinophils—play roles in specific aspects of immune responses but aren’t the primary drivers of neutrophil influx.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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