स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
MECEE-PG – MD/MS/MDS Entrance · २,८६५ प्रश्न
२,८६५ प्रश्न उपलब्ध। मोड छान्नुहोस्:
MD/MS प्रवेश: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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Drug-induced lupus erythematosus is most commonly associated with:
सही उत्तर: ग) Procainamide
Procainamide and hydralazine, especially in slow acetylators, frequently cause drug-induced lupus with anti-histone antibodies. Renal and CNS involvement are rare in drug-induced lupus.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Phocomelia is the classic teratogenic effect of:
सही उत्तर: क) Thalidomide
Thalidomide taken in early pregnancy causes limb defects such as phocomelia. Warfarin causes fetal warfarin syndrome with nasal hypoplasia and stippled epiphyses.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Omeprazole reduces gastric acid secretion by:
सही उत्तर: ख) Irreversibly inhibiting H+/K+-ATPase in parietal cells
Proton pump inhibitors are activated in the acidic canaliculus and bind covalently to the proton pump, so acid secretion recovers only when new pumps are made. Ranitidine and famotidine are H2 blockers.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Sildenafil is contraindicated in patients taking nitrates because both:
सही उत्तर: ग) Increase cGMP, causing severe hypotension
Nitrates increase cGMP production through NO, while sildenafil inhibits its breakdown by PDE5, so together they cause profound vasodilation and hypotension. Sildenafil is a PDE5 inhibitor, not a nitric oxide donor.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Acyclovir is selectively active against herpesvirus-infected cells because it is first phosphorylated by:
सही उत्तर: ख) Viral thymidine kinase
Viral thymidine kinase converts acyclovir to the monophosphate, after which host kinases form the active triphosphate that inhibits viral DNA polymerase. Thymidine kinase-deficient strains are resistant and may need foscarnet.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Primaquine is used in Plasmodium vivax malaria to:
सही उत्तर: ख) Eradicate liver hypnozoites and prevent relapse
Primaquine kills dormant hypnozoites of P. vivax and P. ovale (radical cure) and is also gametocidal. G6PD status should be checked because it can cause haemolysis.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Mesna is given with cyclophosphamide to prevent:
सही उत्तर: क) Haemorrhagic cystitis
The cyclophosphamide metabolite acrolein damages the bladder; mesna binds acrolein in the urine. Dexrazoxane is used to protect against doxorubicin cardiotoxicity.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Ketamine produces 'dissociative anaesthesia' mainly by blocking:
सही उत्तर: क) NMDA receptors
Ketamine is a non-competitive NMDA receptor antagonist providing analgesia and amnesia while maintaining airway reflexes and blood pressure. Propofol and benzodiazepines act mainly through GABA-A receptors.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Prolonged apnoea after succinylcholine is seen in patients with a genetic deficiency of:
सही उत्तर: घ) Plasma pseudocholinesterase (butyrylcholinesterase)
Succinylcholine is normally broken down quickly by plasma pseudocholinesterase; in atypical enzyme variants the block can last hours. N-acetyltransferase polymorphism affects isoniazid metabolism.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The drug used to treat malignant hyperthermia is:
सही उत्तर: क) Dantrolene
Dantrolene blocks the ryanodine receptor (RyR1), stopping calcium release from the sarcoplasmic reticulum. Halothane and succinylcholine are triggers of malignant hyperthermia.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
यी अभ्यास प्रश्न हुन्, आधिकारिक प्रश्न होइनन्। पाठ्यक्रम, विज्ञापन र नतिजाका लागि सम्बन्धित निकायको आधिकारिक वेबसाइट हेर्नुहोस्। उत्तरमा गल्ती भेटे प्रश्नमुनिको "टिप्पणी / गल्ती रिपोर्ट" मा लेख्नुहोस्।
नमस्ते! पाठ्यक्रम, सामान्य ज्ञान, भाषा परीक्षा वा कुनै प्रश्नको उत्तर बुझ्न सोध्नुहोस्।
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