चिकित्सा स्नातकोत्तर प्रवेश (MECEE-PG) MD / MS / MDS प्रवेश परीक्षा तयारी
चिकित्सा स्नातकोत्तर प्रवेश (MECEE-PG) – MD / MS / MDS प्रवेश परीक्षा
MECEE-PG – MD/MS/MDS · MECEE-PG (MD/MS/MDS)
२,८६५ प्रश्न उपलब्ध। मोड छान्नुहोस्:
MD/MS/MDS प्रवेश: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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Lesch–Nyhan syndrome results from deficiency of:
सही उत्तर: ग) Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
HGPRT deficiency blocks the purine salvage pathway, causing hyperuricaemia, gout, intellectual disability and self-mutilation; it is X-linked recessive. Adenosine deaminase deficiency causes severe combined immunodeficiency.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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McArdle disease (glycogen storage disease type V) is caused by deficiency of:
सही उत्तर: ग) Muscle glycogen phosphorylase
Lack of muscle glycogen phosphorylase causes exercise intolerance, cramps and myoglobinuria with no rise in blood lactate after ischaemic exercise. Liver phosphorylase deficiency is Hers disease (type VI).
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Von Gierke disease (glycogen storage disease type I) is due to deficiency of:
सही उत्तर: ग) Glucose-6-phosphatase
Without glucose-6-phosphatase the liver cannot release free glucose, causing severe fasting hypoglycaemia, lactic acidosis, hyperuricaemia and hepatomegaly. Acid alpha-glucosidase deficiency is Pompe disease (type II).
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Urine that darkens on standing and ochronosis are features of a deficiency of:
सही उत्तर: घ) Homogentisate oxidase
In alkaptonuria, homogentisic acid accumulates and oxidises to a black pigment that darkens urine and deposits in connective tissue (ochronosis), causing arthritis. Branched-chain keto acid dehydrogenase deficiency causes maple syrup urine disease.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Classical phenylketonuria is caused by deficiency of:
सही उत्तर: ग) Phenylalanine hydroxylase
Phenylalanine hydroxylase converts phenylalanine to tyrosine; its deficiency leads to accumulation of phenylalanine, intellectual disability and a musty odour. Tyrosine becomes an essential amino acid in PKU.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The rate-limiting enzyme of heme synthesis is:
सही उत्तर: क) ALA synthase
Delta-aminolevulinic acid synthase, which needs pyridoxal phosphate, catalyses the first and rate-limiting step and is feedback-inhibited by heme. ALA dehydratase and ferrochelatase are the enzymes inhibited by lead.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The rate-limiting enzyme of the urea cycle is:
सही उत्तर: ग) Carbamoyl phosphate synthetase I
Mitochondrial carbamoyl phosphate synthetase I is rate-limiting and requires N-acetylglutamate as an allosteric activator. Ornithine transcarbamoylase deficiency is, however, the most common inherited urea cycle disorder.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The rate-limiting enzyme of glycolysis is:
सही उत्तर: क) Phosphofructokinase-1
PFK-1 catalyses the committed step (fructose-6-phosphate to fructose-1,6-bisphosphate); it is activated by AMP and fructose-2,6-bisphosphate and inhibited by ATP and citrate. Hexokinase and pyruvate kinase are also regulated but are not the rate-limiting step.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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A patient presents with dermatitis, diarrhoea and dementia. The vitamin most likely deficient is:
सही उत्तर: ख) Niacin
The three Ds (dermatitis, diarrhoea, dementia, and eventually death) define pellagra, due to niacin deficiency. It can also occur in Hartnup disease and carcinoid syndrome because tryptophan is a niacin precursor.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Vitamin K is required for which post-translational modification of clotting factors?
सही उत्तर: क) Gamma-carboxylation of glutamate residues
Vitamin K is a cofactor for gamma-glutamyl carboxylase, which modifies factors II, VII, IX and X (and proteins C and S) so they can bind calcium. Warfarin acts by inhibiting vitamin K epoxide reductase.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
यी अभ्यास प्रश्न हुन्, आधिकारिक प्रश्न होइनन्। पाठ्यक्रम, विज्ञापन र नतिजाका लागि सम्बन्धित निकायको आधिकारिक वेबसाइट हेर्नुहोस्। उत्तरमा गल्ती भेटे प्रश्नमुनिको "टिप्पणी / गल्ती रिपोर्ट" मा लेख्नुहोस्।
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