प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी – Pathology, Microbiology & Pharmacology MCQ
प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी – MD/MS प्रवेश
Pathology, Microbiology & Pharmacology · MECEE-PG – MD/MS/MDS Entrance · ४०८ प्रश्न
४०८ प्रश्न उपलब्ध। मोड छान्नुहोस्:
प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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A patient presents with fever, malaise, and neutropenia following exposure to contaminated water. Gram staining reveals the presence of catalase-positive, oxidase-positive bacteria. Which bacterial species is MOST likely responsible for causing this infection?
सही उत्तर: घ) D. Klebsiella pneumoniae
*Pseudomonas aeruginosa* (option C) is a common opportunistic pathogen that frequently causes febrile neutropenia following water exposure, exhibiting the characteristic catalase and oxidase positive properties. The other options are less likely given this clinical presentation.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following pathological conditions involves granulomatous inflammation characterized by non-caseating necrosis and is often associated with exposure to Mycobacterium species?
सही उत्तर: ग) C. Tuberculosis
Tuberculosis (option C) is definitively defined by its characteristic granulomatous inflammation with non-caseating necrosis, directly linked to *Mycobacterium* infection. The other options describe different inflammatory processes that don’t fit this specific pathological presentation.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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In the context of wound healing, what does ‘scarring’ primarily represent? a) Rapid proliferation of fibroblasts followed by collagen degradation b) Deposition of elastin fibers resulting in increased tissue elasticity c) A dense deposit of collagen fibers with limited cellularity and reduced vascularization d) Extensive angiogenesis creating a highly vascularized granulation tissue
सही उत्तर: ग) c) A dense deposit of collagen fibers with limited cellularity and reduced vascularization
The correct answer is (c). Scarring represents the formation of dense, poorly organized collagen. The other options describe characteristics of normal granulation tissue – high cellularity, abundant blood vessels, and elastin deposition.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The classical hay fever reaction (immediate hypersensitivity) involves which key immunological mechanism? a) Complement activation through the alternative pathway b) Binding of IgE antibodies to mast cells and basophils c) Direct cytotoxicity mediated by T lymphocytes d) Antibody-mediated destruction of erythrocytes
सही उत्तर: ख) b) Binding of IgE antibodies to mast cells and basophils
The correct answer is (b). The classical hay fever reaction (immediate hypersensitivity) involves the binding of allergen-specific IgE antibodies to surface receptors on mast cells and basophils, triggering degranulation and release of inflammatory mediators. The alternative pathway activation in complement is a component of later stages of inflammation, not the primary initiating event.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following histological findings would most strongly suggest a metastatic carcinoma? a) Extensive keratinization and formation of hornstones b) Presence of fibrinoid necrosis within glomerular capillaries c) Stromal desmoplasia, loss of nuclear polarity, and frequent mitoses d) Formation of lipid-laden macrophages in the liver
सही उत्तर: घ) d) Formation of lipid-laden macrophages in the liver
The correct answer is (c). The features described – stromal desmoplasia, loss of nuclear polarity, and increased mitotic activity – are highly characteristic of a metastatic carcinoma's aggressive growth pattern. The other options represent characteristics of different pathologies such as squamous cell carcinomas or non-alcoholic fatty liver disease.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Microbiological evidence for a bacterial abscess typically demonstrates which characteristic? a) Presence of acid-fast bacilli b) Extensive polysaccharide capsule production by the causative organism c) Numerous neutrophils and bacteria within the pus fluid d) Obligate anaerobic conditions within the lesion
सही उत्तर: ग) c) Numerous neutrophils and bacteria within the pus fluid
The correct answer is (c). Pus formation – characterized by abundant white blood cells and bacterial presence - is a classic sign of a bacterial abscess. Acid-fast bacilli are associated with *Mycobacterium* infections, polysaccharide capsules are primarily produced by some bacteria (like *Streptococcus*), and obligate anaerobes usually don't reside in the pus.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following mechanisms primarily contributes to the steady-state drug concentration achieved after continuous intravenous administration? a) Rapid clearance by kidneys b) First-order elimination kinetics c) Accumulation in tissues due to prolonged exposure d) Zero-order elimination kinetics
सही उत्तर: घ) d) Zero-order elimination kinetics
The correct answer is (d) because zero-order kinetics describes a situation where the rate of drug removal doesn't change with increasing drug concentration. The other options describe mechanisms that would result in a different plasma concentration profile. A first order reaction would quickly decrease the plasma level.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Warthin-Finkeldey multinucleated giant cells, often observed in the lymphoid tissue of patients with infectious mononucleosis (IM), are predominantly derived from which cellular lineage?
सही उत्तर: ग) T lymphocytes
Warthin-Finkeldey cells are large, multinucleated cells originating from macrophages that engulf engulfed pathogens or foreign material. They’re a key feature of IM and other conditions involving lymphocyte infiltration and subsequent macrophage activation.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Psammoma bodies – characterized by concentric calcification – are most frequently found within which pathological context?
सही उत्तर: क) Granulomatous Diseases
Psammoma bodies are characteristic of the chronic inflammatory conditions, particularly tuberculosis (TB) and sarcoidosis. These appear as concentric calcium deposits within granulomas formed in response to infection or inflammation. The other options represent distinct pathologies with different calcification patterns.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which of the following genetic defects is most frequently implicated in the development of Factor V Leiden mutation, a significant risk factor for thrombophilia amongst individuals with European ancestry?
सही उत्तर: ग) Factor V Leiden Mutation
The Factor V Leiden mutation is a common genetic cause of thrombophilia, particularly in populations of Northern European descent. It results in a hypercoagulable state by altering the protein’s structure. While other options relate to inherited blood disorders, they do not specifically explain the mechanism of increased thrombosis associated with Factor V Leiden.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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