स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
MECEE-PG – MD/MS/MDS Entrance · २,८६५ प्रश्न
२,८६५ प्रश्न उपलब्ध। मोड छान्नुहोस्:
MD/MS प्रवेश: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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Dose-limiting peripheral neuropathy with relatively little myelosuppression is characteristic of:
सही उत्तर: ख) Vincristine
Vincristine binds tubulin and causes neurotoxicity (paraesthesia, areflexia, constipation) with little marrow suppression, whereas vinblastine is mainly myelosuppressive.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Pulmonary fibrosis is a characteristic toxicity of which anticancer drug that causes little bone marrow suppression?
सही उत्तर: क) Bleomycin
Bleomycin causes dose-related pulmonary fibrosis and skin pigmentation but is relatively marrow sparing.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Dose-related cardiomyopathy is the characteristic toxicity of:
सही उत्तर: क) Doxorubicin
Anthracyclines such as doxorubicin generate free radicals causing cumulative dose-dependent cardiomyopathy; dexrazoxane offers protection.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Haemorrhagic cystitis caused by cyclophosphamide is prevented by co-administration of:
सही उत्तर: ख) Mesna
The metabolite acrolein damages the bladder; mesna binds and inactivates acrolein in the urine.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Linezolid inhibits bacterial protein synthesis by:
सही उत्तर: घ) Preventing formation of the 70S initiation complex
Linezolid (an oxazolidinone) binds the 50S subunit's 23S rRNA and blocks formation of the initiation complex, so cross-resistance with other classes is rare.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Patients taking metronidazole are advised to avoid alcohol because of the risk of:
सही उत्तर: ग) A disulfiram-like reaction
Metronidazole inhibits aldehyde dehydrogenase, so alcohol causes acetaldehyde accumulation with flushing, nausea, vomiting and palpitations.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Fluoroquinolones such as ciprofloxacin act by inhibiting:
सही उत्तर: ख) DNA gyrase and topoisomerase IV
Fluoroquinolones inhibit bacterial type II topoisomerases (DNA gyrase and topoisomerase IV), blocking DNA replication.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Macrolide antibiotics such as azithromycin inhibit bacterial protein synthesis by binding to the:
सही उत्तर: क) 50S ribosomal subunit
Macrolides bind the 23S rRNA of the 50S subunit and block translocation; aminoglycosides and tetracyclines act on the 30S subunit.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Vancomycin inhibits bacterial cell wall synthesis by binding to:
सही उत्तर: घ) D-alanyl-D-alanine terminus of peptidoglycan precursors
Vancomycin binds the D-Ala-D-Ala end of cell wall precursors, blocking transglycosylation; resistance (e.g. VRE) arises when this changes to D-Ala-D-lactate.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Clavulanic acid is combined with amoxicillin because it:
सही उत्तर: ग) Inhibits bacterial β-lactamases
Clavulanic acid is a β-lactamase inhibitor that protects amoxicillin from enzymatic destruction, extending its spectrum.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
यी अभ्यास प्रश्न हुन्, आधिकारिक प्रश्न होइनन्। पाठ्यक्रम, विज्ञापन र नतिजाका लागि सम्बन्धित निकायको आधिकारिक वेबसाइट हेर्नुहोस्। उत्तरमा गल्ती भेटे प्रश्नमुनिको "टिप्पणी / गल्ती रिपोर्ट" मा लेख्नुहोस्।
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