स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
स्नातकोत्तर मेडिकल प्रवेश (MECEE-PG)
MECEE-PG – MD/MS/MDS Entrance · २,८६५ प्रश्न
२,८६५ प्रश्न उपलब्ध। मोड छान्नुहोस्:
MD/MS प्रवेश: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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Ketamine produces dissociative anaesthesia mainly by blocking:
सही उत्तर: क) NMDA glutamate receptors
Ketamine is a non-competitive NMDA receptor antagonist that produces analgesia and dissociation while largely preserving airway reflexes and blood pressure.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Pulmonary fibrosis, thyroid dysfunction and corneal microdeposits are adverse effects of:
सही उत्तर: ग) Amiodarone
Amiodarone is iodine-rich and lipophilic; it can cause pulmonary fibrosis, hypo- or hyperthyroidism, corneal deposits, photosensitivity and hepatotoxicity.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Phocomelia in babies exposed in utero is the classic teratogenic effect of:
सही उत्तर: घ) Thalidomide
Thalidomide taken in early pregnancy caused limb reduction defects (phocomelia), leading to modern drug regulation.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Loop diuretics such as furosemide act by inhibiting the:
सही उत्तर: ख) Na⁺–K⁺–2Cl⁻ cotransporter in the thick ascending limb
Furosemide blocks NKCC2 in the thick ascending limb of the loop of Henle; thiazides block the Na⁺–Cl⁻ cotransporter in the DCT.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Clopidogrel inhibits platelet aggregation by:
सही उत्तर: क) Irreversibly blocking the P2Y12 ADP receptor
Clopidogrel is a prodrug whose active metabolite irreversibly blocks the P2Y12 receptor, preventing ADP-induced platelet activation.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Aspirin inhibits platelet aggregation for the life of the platelet because it:
सही उत्तर: घ) Irreversibly acetylates cyclo-oxygenase
Aspirin acetylates COX-1 irreversibly; platelets lack nuclei and cannot make new enzyme, so thromboxane A2 production stops for about 7–10 days.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Neostigmine, unlike physostigmine, does not cross the blood–brain barrier because it is a:
सही उत्तर: ख) Quaternary ammonium compound
Neostigmine carries a permanent positive charge (quaternary ammonium), so it acts peripherally; physostigmine is a tertiary amine that enters the CNS.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Buprenorphine acts at the μ-opioid receptor as a:
सही उत्तर: ग) Partial agonist
Buprenorphine is a high-affinity partial μ agonist with a ceiling effect on respiratory depression, useful in opioid substitution therapy.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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The therapeutic index of a drug is defined as:
सही उत्तर: ग) TD50 ÷ ED50
Therapeutic index = median toxic (or lethal) dose ÷ median effective dose; a larger value indicates a safer drug.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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At high doses, which drug shows zero-order (saturation) kinetics?
सही उत्तर: ख) Phenytoin
Phenytoin, ethanol and high-dose aspirin saturate their metabolising enzymes, so a fixed amount is eliminated per unit time and small dose increases cause large level rises.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
यी अभ्यास प्रश्न हुन्, आधिकारिक प्रश्न होइनन्। पाठ्यक्रम, विज्ञापन र नतिजाका लागि सम्बन्धित निकायको आधिकारिक वेबसाइट हेर्नुहोस्। उत्तरमा गल्ती भेटे प्रश्नमुनिको "टिप्पणी / गल्ती रिपोर्ट" मा लेख्नुहोस्।
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