प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी – Pathology, Microbiology & Pharmacology MCQ
प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी – MD/MS प्रवेश
Pathology, Microbiology & Pharmacology · MECEE-PG – MD/MS/MDS Entrance · ४०८ प्रश्न
४०८ प्रश्न उपलब्ध। मोड छान्नुहोस्:
प्याथोलोजी, माइक्रोबायोलोजी र फार्माकोलोजी: प्रश्न र उत्तर
सही लागेको विकल्पमा थिच्नुहोस्। सही भए हरियो, गलत भए रातो देखिन्छ; ३ सेकेन्डपछि सही उत्तर र व्याख्या देखिन्छ।
सही: ० / ०
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Proton pump inhibitors such as omeprazole reduce gastric acid by irreversibly inhibiting:
सही उत्तर: ख) H⁺/K⁺-ATPase of parietal cells
PPIs are activated in the acidic canaliculus and covalently inhibit the parietal cell H⁺/K⁺-ATPase, the final step of acid secretion.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Quinine and chloroquine are mainly active against which stage of the malaria parasite?
सही उत्तर: घ) Erythrocytic schizonts
Quinine and chloroquine are blood schizonticides; primaquine is needed to kill hepatic hypnozoites of P. vivax and P. ovale.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which inhalational anaesthetic agent has the lowest blood:gas partition coefficient and therefore the fastest induction and recovery?
सही उत्तर: क) Desflurane
A low blood:gas partition coefficient means low blood solubility and rapid equilibration; desflurane (about 0.42) is lower than sevoflurane, isoflurane and halothane.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Which antiepileptic drug is a voltage-gated sodium channel blocker that can cause hyponatraemia (SIADH-like) and Stevens–Johnson syndrome, especially in carriers of HLA-B*15:02?
सही उत्तर: ग) Carbamazepine
Carbamazepine blocks Na⁺ channels; it can cause hyponatraemia and, in HLA-B*15:02 carriers (common in South-East Asians), severe SJS/TEN.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Methotrexate exerts its cytotoxic effect mainly by inhibiting:
सही उत्तर: घ) Dihydrofolate reductase
Methotrexate binds dihydrofolate reductase, depleting tetrahydrofolate needed for thymidylate and purine synthesis; 5-FU inhibits thymidylate synthase.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Imatinib, used in chronic myeloid leukaemia, acts by inhibiting:
सही उत्तर: ग) BCR-ABL tyrosine kinase
Imatinib competitively blocks the ATP-binding site of the BCR-ABL fusion tyrosine kinase produced by the Philadelphia chromosome; it also inhibits c-KIT.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Dose-limiting peripheral neuropathy with relatively little myelosuppression is characteristic of:
सही उत्तर: ख) Vincristine
Vincristine binds tubulin and causes neurotoxicity (paraesthesia, areflexia, constipation) with little marrow suppression, whereas vinblastine is mainly myelosuppressive.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Pulmonary fibrosis is a characteristic toxicity of which anticancer drug that causes little bone marrow suppression?
सही उत्तर: क) Bleomycin
Bleomycin causes dose-related pulmonary fibrosis and skin pigmentation but is relatively marrow sparing.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Dose-related cardiomyopathy is the characteristic toxicity of:
सही उत्तर: क) Doxorubicin
Anthracyclines such as doxorubicin generate free radicals causing cumulative dose-dependent cardiomyopathy; dexrazoxane offers protection.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
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Haemorrhagic cystitis caused by cyclophosphamide is prevented by co-administration of:
सही उत्तर: ख) Mesna
The metabolite acrolein damages the bladder; mesna binds and inactivates acrolein in the urine.
💬 टिप्पणी / गल्ती रिपोर्ट (०)
यी अभ्यास प्रश्न हुन्, आधिकारिक प्रश्न होइनन्। पाठ्यक्रम, विज्ञापन र नतिजाका लागि सम्बन्धित निकायको आधिकारिक वेबसाइट हेर्नुहोस्। उत्तरमा गल्ती भेटे प्रश्नमुनिको "टिप्पणी / गल्ती रिपोर्ट" मा लेख्नुहोस्।
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